Cruz-Lemini M, Vázquez JC, Ullmo J, et al. - Researchers performed a meta-analysis of studies published to evaluate the effectiveness of low-molecular-weight heparin for the prevention of preeclampsia and other placenta-related complications in high-risk women. In total, 15 studies were included. The sample consisted of 2,795 participants. In high-risk women and when treatment was begun before 16 weeks’ gestation, low-molecular-weight heparin use was linked to a significant reduction in the risk of preeclampsia and other placenta-mediated complications. Compared with low-dose aspirin alone, combined treatment with low-dose aspirin was related to a significant reduction in the risk of preeclampsia. However, since there is significant clinical and statistical variation, these findings should be confirmed in massive, well-designed clinical trials.