Azukaitis K, et al. - In this post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, researchers assessed the significance of urinary epidermal growth factor (uEGF) in pediatric chronic kidney disease (CKD). Participants included prospectively followed children of 6–17 years of age, having baseline estimated glomerular filtration rate (eGFR) of 10–60 ml/min/1.73 m². Independent of age, sex, baseline eGFR, primary kidney disease, proteinuria, and systolic blood pressure, a decreased risk of CKD progression was found in relation to higher uEGF/Cr in a Cox proportional hazards model. Also, uEGF/Cr offered an improved prediction of the 1-, 2- and 3-year risk of CKD progression. Overall, uEGF could have utility as a predictive biomarker for CKD progression in children with CKD.