Kim YS, Lee SH, Park SG, et al. - In this prospective study of 2,735 individuals in a hospital health check-up setting, experts examined the association of total adiponectin, high-molecular-weight (HMW) adiponectin, and leptin with the development and advancement of non-alcoholic fatty liver (NAFL) irrespective of gender and weight change over a maximum of 8.5 years. It was discovered that irrespective of pathophysiological factors including obesity and insulin resistance, the development of NAFL may be prognosticated by the low levels of total and HMW adiponectin. This predictability in females was evident. Also, leptin was an important prognosticator for NAFL in individuals with weight gain.