Putra IGM, Warsita IGN, Suwiyoga K, et al. - Researchers sought to prove the value of low expression of collagen type-1 in sacrouterine ligament as a risk factor for the occurrence of stage III–IV uterine prolapse. Using case-control approach, they conducted an observational study including a total of 22 cases of stage III–IV uterine prolapse and 22 cases of non-uterine prolapse as control group. Samples were taken from sacrouterine ligament of cases with stage III–IV uterine prolapse compared with non-prolapse uterine who had undergone total hysterectomy. Per Chi-square analysis with 95 % confidence interval, low expression of collagen type-1 was 6 times more likely to be the risk factor of stage III–IV uterine prolapse.