Scarpa A, Ralli M, Cassandro C, et al. - In this investigation involving 48 patients with unilateral intractable Meniere disease (MD), researchers tested the safety and effectiveness of low-dose intratympanic (IT) gentamicin on vertigo attacks in MD utilizing a clinical symptomatology-based method in which administration was repeated only when vertigo attacks recurred, with an interval of 2 weeks between injections. All participants in the study got one to five injections of 0.5 ml of 10 mg of gentamicin (80 mg/2 ml) with an injection interval of 2 weeks. According to results, before treatment patients had an average of 4.4 vertigo attacks/month and after treatment, the average number declined to 0.52. Findings revealed that there was no hearing deterioration in all patients treated. Results of this study suggested that low-dose IT gentamicin administration based on clinical symptomatology can produce a satisfactory control of vertigo attacks after treatment. It was noted that such protocol had an impact mainly on the vestibular function as illustrated by the significant reduction in VOR gain in the affected side avoiding cochlear destruction.