Heffron SP, Ruuth MK, Xia Y, et al. - Among patients with peripheral artery disease (PAD) receiving lower extremity revascularization (LER), this inquiry was performed to ascertain whether LDL aggregation is related to major adverse cardiovascular events (MACE: myocardial infarction, stroke, cardiovascular death). This study involved 239 participants, from whom blood was collected at baseline and who were observed prospectively for one-year. According to the findings, a significantly increased MACE risk after LER was observed, even after multivariable adjustment, in patients with PAD with the most rapid LDL aggregation in the setting of very well controlled LDL-cholesterol. The classification specificity of an established risk prediction instrument was further improved by this measure. A broader inquiry of this assay for risk stratification in cases with atherosclerotic CVD is supported.