Parra SG, et al. - In medically-underserved areas in Texas, high-resolution microendoscopy (HRME)-a low-cost, in vivo imaging method that can recognize high-grade precancerous cervical lesions (CIN2+) at the point-of-care- was assessed for its performance and the results were compared to a tertiary academic medical center. The final analysis included 174 women (227 cervical sites), of these, a histopathological diagnosis of CIN2+ was received by 12% (11% of cervical sites). Sensitivity and a specificity of 84% and 45%, respectively, of a colposcopic impression of low-grade precancer or greater to detect CIN2+ was reported, on a per-site basis. For detecting CIN2+, increased specificity was provided by HRME imaging vs traditional colposcopy. Across various clinical settings, consistent HRME image quality was identified.