Willemse S, et al. - Given the increasing incidence of hepatocellular carcinoma (HCC) in patients co-infected with HIV and hepatitis B virus (HBV) or hepatitis C virus (HCV) and that guidelines recommend HCC screening every 6 months in patients with cirrhosis, researchers examined HBV/HCV-HIV-co-infected patients with cirrhosis for their compliance with HCC screening guidelines. From 4 European prospective cohorts participating in the COHERE collaboration, they followed 646 HIV-patients with the diagnosis of cirrhosis: 518 (80%) HCV-, 85 (13%) HBV- and 43 (7%) HBV/HCV-co-infected. Compliance with HCC screening guidelines was defined as one ultrasound every 6 months. As per outcomes, cirrhotic HIV-patients co-infected with HBV and/or HCV in Europe show low compliance with HCC screening guidelines. They emphasize addressing this situation urgently in light of an aging population and the increasing prevalence of liver cirrhosis.