Lu W, et al. - Researchers tested the hypothesis that circulating total adiponectin or certain fractions may represent a promising biological candidate in modulating the risk of colorectal cancer. An aggregate of 31 papers containing 48 qualified studies (7,554 patients with colorectal cancer and 9,798 controls) were meta-analyzed. The study findings suggested that low circulating total adiponectin, particularly its non-high-molecular weight (HMW) fraction, represents a promising risk factor for colorectal cancer.