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Low carotid flow pulsatility index correlates with the presence of unruptured intracranial aneurysms

Journal of the American Heart Association Jun 25, 2021

Igase M, Igase K, Okada Y, et al. - This study was intended to evaluate cases of incidental unruptured intracranial aneurysm (UIA) discovered on screening magnetic resonance angiography to identify hemodynamic and atherosclerotic risk factors. Researchers retrospectively examined the data of 1,376 healthy older individuals (age range, 31–91 years) without cerebro‐ or cardiovascular diseases who underwent brain magnetic resonance angiography as part of a medical checkup program at a health screening center. The evidence showed that the presence of UIAs is associated with lower carotid flow pulsatility index and increased low‐density lipoprotein cholesterol in the data from a population of healthy older volunteers. Moreover, a decreased carotid flow pulsatility index may influence low‐density lipoprotein cholesterol elevation by some molecular pathways and influence the development of cerebral aneurysms. In addition, this may guide aneurysm screening indications for institutions where magnetic resonance angiography is not routine.

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