Low bone mineral density is associated with hypogonadism and cranial irradiation in male childhood cancer survivors
Osteoporosis International Feb 12, 2020
Isaksson S, Bogefors K, Åkesson K, et al. - Researchers tried to find out whether bone mineral density was related to testosterone deficiency and/or previous cancer treatment in men who were childhood cancer survivors. A total of 125 childhood cancer survivors (CCS) (median age 33.7 at inclusion; 9.6 at diagnosis) and 125 age-matched population controls were recruited in this study. Serum testosterone and luteinizing hormone were measured and bone mineral density (BMD) at the total hip and lumbar spine L1–L4 measured. This study analyzed the mean difference in BMD (g/cm2; 95% CI) between CCS and controls. The results showed that CCS with hypogonadism or previously treated with cranial irradiation are at raised risk of impaired bone health. In the future follow-up of these men, prevention of osteoporosis should be considered as an important part.
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