Liu Y, et al. - Researchers assessed the expression, biological functions and molecular mechanisms of KCNJ15 in renal cell carcinoma (RCC). They used kidney cancer tissue, paired adjacent normal tissue, and cell lines to assess KCNJ15 mRNA expression by using qRT-PCR. Using Kaplan-Meier analysis and Cox proportional hazards analysis, they determined the clinical and prognostic significance of KCNJ15 in RCC. In vitro study of KCNJ15 impacts on kidney cancer cells was also performed. Remarkable inhibition of RCC cell proliferation, migration, and colony formation, arrest in the cell cycle and apoptosis of RCC cells in vitro were all resulted from overexpression of KCNJ15. These impacts could be regulated by its influences on the epithelial mesenchymal transition (EMT) process and matrix metalloproteinase (MMP)-7 and p21 expression. Overall, a possible role of KCNJ15 as a tumour suppressor in RCC was suggested. KCNJ15 may be a target for RCC therapy.