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Loss of DNA damage response in neuroblastoma and utility of a PARP inhibitor

Journal of the National Cancer Institute Nov 24, 2017

Takagi M et al. -Deletions within the 11q region occur in 11%-48% of neuroblastomas. In the current study, genomic alterations of DDR-associated genes, including ATM, were demonstrated in approximately one-half of neuroblastomas. Moreover, DDR-defective neuroblastoma cell lines were shown to be sensitive to PARP inhibitors.

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