Pestaña-Fernández M, Rubio-Rivas M, Tolosa-Vilella C, et al. - Experts examined a cohort of people with systemic sclerosis (SSc) - correlated pulmonary arterial hypertension (PAH) from the Spanish Scleroderma Registry (RESCLE) in order to estimate the effectiveness of monotherapy vs combination therapy in these individuals with SSc–associated PAH from the Spanish Scleroderma. A total of 76 people out of 1,817 had SSc-related PAH and 34 people obtained. Sequential combination therapy was obtained to be an autonomous protective factor, while upfront combination therapy revealed a trend. Therefore, combination sequential therapy increased survival in these cohorts.