Abé C, Ching CRK, Liberg B, et al. - Cortical and subcortical structural brain abnormalities are observed in correlation with bipolar disorder (BD). In this study, insights into disease progression in BD are provided, and the importance of mania prevention in BD treatment is highlighted.

• From the ENIGMA-BD Working Group, including 307 BD patients and 925 healthy controls (HC), collection of longitudinal structural MRI and clinical data was done from 14 sites worldwide.

• There was no accelerated cortical thinning but faster ventricular enlargements in BD.

• Frequent manic episodes were associated with faster cortical thinning, primarily in the prefrontal cortex.