Won KB, et al. - In 1,568 subjects who underwent serial coronary computed tomography angiography with available body mass index (BMI) at baseline and follow-up, researchers assessed the coronary plaque volume change (PVC) according to the change of percent BMI and categorical BMI. Median inter-scan period was 3.3 years. At both scans, coronary plaque was quantitatively assessed. Three BMI (kg/m²) groups were defined (normal: <25.0; overweight: 25.0–29.9; and obesity: ≥30.0). In all BMI groups, no significant differences in annualized PVC were observed according to the 5% change of BMI. After adjusting confounding factors, no significant link was observed between the percent change of BMI and the annualized PVC. Factors that were found to be independently associated with coronary plaque progression were male gender, baseline plaque volume, and baseline overweight or obesity. Although baseline BMI was associated with changes in coronary plaque volume, no associations were found for longitudinal small changes in BMI over the near term.