Challa DNV, Kvrgic Z, Crowson CS, et al. - Researchers undertook this retrospective case–control study to define longitudinal predictors of discordance between patients with rheumatoid arthritis (RA) and their healthcare providers, where patient global evaluation of disease activity is substantially higher as compared with provider global evaluation. Overall 102 cases with positive discordance (ie, ≥ 25 mm between patient and provider global assessments) as well as 102 controls without discordance, matched for age, gender, RA duration, and Clinical Disease Activity Index (CDAI) score, were examined. Higher rates of discordant visits during the 4 years prior to the index visit as well as a higher CDAI score and DAS28-CRP (Disease Activity Score in 28 joints (3-variable) using the C-reactive protein level) earlier in the disease course was noted in cases vs controls. Antinuclear antibodies, nonerosive disease, prior depression, or previous use of antidepressants or fibromyalgia medications were more frequently noted in cases. Cases and controls did not differ in terms of disease-modifying medication use. These data inform novel hypotheses regarding the links of disease activity and antinuclear antibodies to the later occurrence of positive discordance in RA patients.