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Longitudinal observation of antibody responses for 14 months after SARS-CoV-2 infection

Clinical Immunology Aug 11, 2021

Dehgani-Mobaraki P, Zaidi AK, Yadav N, et al. - For future health policy implementation, it is crucial to understand antibody responses post SARS-CoV-2 natural infection.

  • Longitudinal analysis of IgG antibody titers in recovered COVID-19 patients after mild and moderately-severe infection revealed persistence of anti-spike-receptor binding domain IgG in 96.8% individuals at 14 months.

  • Significantly higher antibody titers were recorded in patients describing loss of smell and taste during the clinical course of the disease.

  • False-negative rates were higher in correlation with using nucleocapsid protein-based antibody assays and their avoidance is emphasized in routine analysis.

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