Shin JW, et al. - This cohort study was undertaken to determine if progressive macular ganglion cell–inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thinning are predictive for detecting visual field (VF) progression in eyes with high myopia, defined as a spherical equivalent <-6.0 diopters or axial length >26.5 mm. In total, 104 primary open-angle glaucoma (POAG) eyes with high myopia and 104 age- and VF severity-matched POAG eyes without high myopia (mean follow-up, 5.4 years) were involved. Highly myopic eyes with progressive GCIPL thinning had a significantly higher risk of developing VF progression after adjusting for the baseline intraocular pressure or peak intraocular pressure in the multivariable Cox proportional hazard model, while highly myopic eyes with progressive RNFL thinning were not significantly linked to VF progression. Regardless of the presence of high myopia, monitoring macular GCIPL thickness was effective for anticipating glaucoma progression.