Martinez I, et al. - In the present study, concordant and discordant syndemic profiles among 296 pregnant couples and their actor–partner effects longitudinally from pregnancy to 1-year postpartum were evaluated. During pregnancy, there was a significant difference in syndemic score and severity. Among men and women, pregnancy provided an opportunity to reduce syndemic burden. Particularly during the postpartum period, couples-based prevention programs might serve to reduce syndemic risk for both partners.