Dobrowolski P, Kosinski P, Prejbisz A, et al. - In order to test the hypothesis that an association exist between volume-dependent echocardiographic parameters and Doppler ultrasound parameters of fetal circulation and the uterine artery in uncomplicated pregnancy and to determine the volume-dependent echocardiographic parameters that best depict volume changes and best correlate with Doppler ultrasound of fetal circulation and the uterine artery in healthy pregnancy, researchers determine changes in volume-dependent echocardiographic parameters in uncomplicated pregnancy. They performed analysis of data from 60 healthy pregnant women. A complete echocardiographic study performed at 11 to 13, 20 to 22, and 30 to 32 weeks’ gestation revealed a significant increase in left ventricular end-diastolic volume and left atrial area between 11 to 13 and 20 to 22 weeks’ gestation but not between 20 to 22 and 30 to 32 weeks’ gestation. Observations suggest that a rise occurs in left atrial volume index in an uncomplicated pregnancy, between both the first and second trimesters and the second and third trimesters, and that left atrial volume index has correlation with parameters of Doppler ultrasound of the fetal circulation and the uterine artery. The results expand on the prior finding on the association between maternal cardiovascular adaptation and placentation in women with heart diseases to the population of healthy women with uncomplicated pregnancy.