Dobrowolski P, Kosinski P, Prejbisz A, et al. - Researchers here examined changes of volume-dependent echocardiographic parameters in uncomplicated pregnancy. They tested the hypothesis that there is an association between volume-dependent echocardiographic parameters and Doppler ultrasound parameters of fetal circulation and the uterine artery in uncomplicated pregnancy. In addition, they ascertained the volume-dependent echocardiographic parameters that is best predictive of volume changes and correlates best with Doppler ultrasound of fetal circulation and the uterine artery in healthy pregnancy. Analysis was done on data from 60 healthy pregnant women. Significant increase in left ventricle end diastolic volume and left atrium area was noted between 11-13 and 20-22 weeks but not between 20-22 and 30-32 weeks. Findings revealed that in uncomplicated pregnancy, left atrium volume index raised both between first and second, as well as between second and third trimester, and associated with parameters of Doppler ultrasound of fetal circulation and the uterine artery. This study was identified to be the first study reporting these findings. These findings are in support of the previous observation on the correlation between maternal cardiovascular adaptation and placentation in women with heart diseases to the population of healthy women with uncomplicated pregnancy.