Lee MW, et al. - In this prospective cohort study involving 27 fellow eyes of patients with unilateral choroidal neovascularization (CNV), 33 fellow eyes of patients with unilateral polypoidal choroidal vasculopathy (PCV), and 35 control eyes, researchers discovered longitudinal changes in the ganglion cell-inner plexiform layer (GC-IPL) thickness of the fellow eyes of individuals with neovascular age-related macular degeneration (AMD). Using spectral-domain OCT, GC-IPL thickness was measured twice more with at least 1-year interval between examinations after the initial visit. According to results, the GC-IPL thickness of the fellow eyes was 78.41 ± 9.23, 81.20 ± 5.52, and 81.60 ± 3.83 μm in the CNV, PCV, and control groups, respectively, and they exhibited a significant change over time. The reduction rate in the fellow eyes of the CNV, PCV, and control groups was -0.88, -0.41, and -0.31 μm/yr. Compared with the fellow eyes of patients with unilateral PCV and normal people, the fellow eyes of those with neovascular AMD displayed a greater reduction rate of GC-IPL thickness. Fellow eyes with a thicker GC-IPL at baseline exhibited a greater decline in GC-IPL thickness over time in patients with unilateral neovascular AMD.