Ruderman I, et al. - In a prospective observational study including dialysis patients (mean age 69.6 ± 13.2 years) from a single center, researchers determined the impact of cessation of cinacalcet on the bone and mineral metabolism. Clinical and biochemical outcomes following cessation of cinacalcet were compared with an age- and gender-matched cohort of cinacalcet-naïve dialysis patients. Over 12 months of follow-up in patients who ceased cinacalcet revealed the following biochemical changes: an increase in serum parathyroid hormone (PTH), serum calcium and primary calciprotein particles (CPP) [CPP-I]. Changes in CPP were found to be related to an increase in PTH, calcium and ferritin but an attenuation in serum albumin. With a mortality rate of 19%, two fractures, five cardiovascular events, one episode of calciphylaxis, and one parathyroidectomy was reported over the 12-month period.