Guslits E, Steurer MA, Nawaytou H, et al. - Via performing a retrospective study of 49 infants with congenital diaphragmatic hernia (CDH), researchers examined the value of B-type natriuretic peptide (BNP) as a longitudinal biomarker of clinical outcome in infants with CDH. They performed classification of the cohort by respiratory status at 56 days, based on a proposed definition of bronchopulmonary dysplasia for infants ≥ 32 weeks’ gestation: Good Outcome (alive with no respiratory support) and Poor Outcome (ongoing respiratory support or death). Poor Outcome was reported for 29 infants (59%). Liver herniation into the thorax (90% vs 50%) and non-primary repair (93% vs 35%) were more frequent among infants with Poor vs Good Outcome. Observations revealed accurate predictive value of raised BNP for Poor Outcome in infants with CDH at 3-5 weeks of age, with declining cut-offs over 3-5 weeks of age.