Dai X, et al. - From a large cohort 210 healthy children aged from 2–48 months, the contributors intended to demonstrate how a major challenge that impeded prior investigation of their time-dynamic relationships was the sparse and irregular nature of most longitudinal neuroimaging data could be addressed by applying functional concurrent regression models (FCRMs). An early period was revealed during which the whole brain and regional white matter structure were positively related to cognitive ability. Furthermore, no such association for whole brain white matter volume was found. An increased association among status as measured by maternal education (SES-ME) and cognitive development with a child age was concluded after adjustment in baseline covariates that included SES-ME, infant feeding practice, gender, and birth weight. A new light indicating FCRM as a useful tool for the investigation of the evolving relationships was observed shedding on the emerging patterns of brain and cognitive development.