Kang CK, Kim M, Lee S, et al. - Researchers sought to report on the longitudinal memory T-cell response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) up to 8 months post symptom onset (PSO) according to the severity of illness. Peripheral blood mononuclear cells (PBMCs) were analyzed from a total of 24 patients—seven asymptomatic and nine with mild and eight with severe disease—as well as six healthy volunteers. Persistence of SARS-CoV-2-specific OX40 ⁺ CD137 ⁺ CD4 ⁺ T cells and CD69 ⁺ CD137 ⁺ CD8 ⁺ T cells was observed at 8 months PSO. Patients who had severe illness tended to exhibit greater memory CD4 + T-cell responses than those with mild or asymptomatic disease. Findings thereby suggest persistence of memory response to SARS-CoV-2, based on the frequency and functionality, for 8 months PSO.