Chen JB, et al. - Researchers compared the effect of icodextrin (ICO)- and glucose (GLU)-based solutions on cardiac structure and function in a 2-year longitudinal period in incident-automated peritoneal dialysis (APD) patients, presuming that the use of ICO in peritoneal dialysis (PD) therapy has an advantage in cardiac function via sustained ultrafiltration relative to GLU-based solution. In this 2-year prospective, randomized, open-label, parallel-group study, echocardiographic parameters over 2 years were evaluated using the Friedman test. The links between baseline clinical variables and echocardiographic changes were assessed using generalized linear regression analysis. Findings showed that reasonable cardiac structure and function in incident-APD patients can be maintained by long-dwell icodextrin solution.