Yoon YH, et al. - Among 2,112 patients with ostial or shaft left main coronary artery (LMCA) disease from IRIS-MAIN registry, researchers compared the clinical outcomes between those who underwent percutaneous coronary intervention (PCI) (n = 1,329) or coronary-artery bypass grafting (CABG) (n = 783), to determine the relative treatment effect of each. Findings revealed substantial improvements over time with respect to death; the composite of death, myocardial infarction (MI), or stroke; repeat revascularization; and major adverse cardiac and cerebrovascular events (MACCE; a composite of death, MI, stroke, or repeat revascularization) among those who underwent PCI. A progressive decline in the gap between the outcomes of CABG and PCI was seen due to the marked improvements in PCI outcomes in patients with ostial or shaft LMCA disease.