Alqahtani S, et al. - The long-term trends in the incidence and outcomes of drug overdose out-of-hospital cardiac arrests (OHCA) were investigated via retrospectively reviewing data from the Victorian Ambulance Cardiac Arrest Registry. Emergency medical services (EMS)-attended and EMS-treated cases had incidence of 5.8 and 2.0 per 100,000 person-years, respectively. No significant changes in trend over time were observed. They observed an increase in return of spontaneous circulation from 23% to 34%, event survival from 23% to 30%, and survival to hospital discharge from 4% to 13%. Findings thereby suggest despite no change in the incidence of drug overdose OHCA between 2000 and 2017, significant improvement in the rates of survival occurred. Survival was identified to be independently associated with age, arrest witnessed by bystander or EMS, initial shockable rhythm or pulseless electrical activity, intubation, epinephrine, and sodium bicarbonate administration.