Kariya S, et al. - Among chronic cough patients with chronic rhinosinusitis, researchers determined the influence of clarithromycin and carbocisteine on the changes in lung function. For this study, they recruited 32 chronic cough patients with chronic rhinosinusitis. They excluded cases using inhaled corticosteroids and/or a bronchodilator, asthmatic patients, and cases with abnormal findings on auscultation and/or chest X-ray examination. For 3 months, low-dose clarithromycin treatment was administered to the patients. The long-duration therapy with macrolide antibiotics resulted in improvements in both the lung function and Lund-MacKay computed tomography scores. In non-asthmatic chronic cough patients with normal chest X-ray findings, the beneficial influences of macrolide antibiotics treatment were evident in this study. The improvement of chronic rhinosinusitis was suggested to possibly have some role in the lung condition. The possible usefulness of upper respiratory tract examination and treatment was suggested for the management of chronic cough.