Kariya S, et al. - Researchers conducted this investigation to identify the changes in lung function for chronic cough patients (n = 32) with chronic rhinosinusitis who were treated by clarithromycin and carbocisteine. Excluded from this study were patients using inhaled corticosteroids and/or a bronchodilator, asthmatic patients, and patients with abnormal findings on auscultation and/or chest x-ray examination. In non-asthmatic chronic cough patients with normal chest x-ray findings, the macrolide antibiotics treatment has beneficial impacts on lung function. The improvement of chronic rhinosinusitis in the lung condition may have some role. Examination and treatment of the upper respiratory tract may be useful in managing the chronic cough.