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Long-term transplant outcomes of donor hearts with left ventricular dysfunction

The Journal of Thoracic and Cardiovascular Surgery Mar 14, 2019

Sibona A, et al. - Researchers studied modern long-term survival of transplanted donor hearts with left ventricular dysfunction analyzing data of a large, diverse cohort of adult heart transplants from the United Network for Organ Sharing database between January 2000 and March 2016. They identified a total of 31,712 donor hearts that were transplanted during the study period. Outcomes revealed that transplantation of carefully selected donor hearts with even markedly diminished left ventricular ejection fraction can lead to long-term survival equivalent to normal donor hearts. Hence they recommend not excluding these donor hearts from consideration on the basis of depressed left ventricular ejection fraction alone. In this study, they noted the functional recovery of even the most impaired donor hearts. This emphasizes practicing caution while interpreting studies of left ventricular function in the setting of brain death.
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