Kong F, et al. - Researchers assessed intensity-modulated radiotherapy (IMRT) as a treatment option for locally recurrent nasopharyngeal carcinoma (NPC), focusing on the efficacy as well as toxicities. Participants were 184 previously irradiated NPC patients with recurrent disease and re-irradiated by IMRT between February 2005 to May 2013. In 33, 27, and 54 patients, the disease was re-staged I, II, III, and IV, respectively. Cisplatin-based chemotherapy was used to treat 75% of the patients. Findings demonstrated efficacy of IMRT for patients with locally recurrent NPC. Major severe late complication and leading cause of death was massive hemorrhage of the nasopharynx. Early recurrence was identified as a negative factor for distant metastases–free survival (DMFS). Improved DMFS, but not improved overall survival (OS), could be achieved with combination of chemotherapy. There is a need for optimal salvage treatment strategies focusing on improvement of survival and minimization of late toxicities.