Tack J, et al. - Authors scrutinized the long-term safety of acotiamide and explore the efficacy of acotiamide on postprandial distress syndrome (PDS) symptoms using the validated LPDS, quality of life using SF-36 and SF-NDI, and work productivity using WPAI. Acotiamide demonstrated a change in severity larger than the minimum clinically important difference at weeks 1 and 2 for postprandial fullness and early satiation (meal-related symptoms). An improvement was noted in the quality of life and work productivity from the first measurement (at week 12) up to 1 year. Results affirmed the long-term safety of acotiamide treatment.