Khan F, et al. - In this systematic review and meta-analysis of 18 studies that included over 7,500 patients, researchers identified the rate of a first recurrent venous thromboembolism (VTE) event after discontinuation of anticoagulant treatment in patients with the first episode of unprovoked VTE, and the cumulative incidence for recurrent VTE up to 10 years. According to findings, the risk of recurrent VTE was 10% in the first year after treatment, 16% at 2 years, 25% at 5 years, and 36% at 10 years—with 4% of recurrent VTE events resulting in death in patients with a first episode of unprovoked VTE who completed at ≥ 3 months of anticoagulant treatment. The authors noted that these estimates should inform guidelines for clinical practice, enhance trust in counselling patients about their prognosis, and help guide decision-making on long-term management of unprovoked VTE.