Jacob L, et al. - Researchers followed a large cohort of transient ischemic attack (TIA) patients followed in general practices in Germany with the goal to determine the long-term risk of stroke in this cohort and to assess the associated predictors. They assessed 19,824 patients with an initial TIA diagnosis who were followed up in one of 1,262 general practices in Germany between January 2007 and December 2016. Among these, 18.3% of individuals were diagnosed with stroke within 10 years of the initial TIA diagnosis. They observed a positive association of age with stroke, with hazard ratios (HRs) ranging from 1.88 in patients aged 51-60 years to 4.00 in those aged > 80 years (reference group: patients aged ≤ 50 years). Furthermore, the risk of stroke is additionally influenced by male gender, hypertension, diabetes mellitus, atrial fibrillation, and ischemic heart diseases. Finally, protective factors comprise new oral anticoagulants, heparins, diuretics, angiotensin II receptor blockers, and platelet aggregation inhibitors.