Jamil ML, Keeley J, Sood A, et al. - A post hoc analysis of individuals within the Eastern Cooperative Oncology Group—American College of Radiology Imaging Network (ECOG-ACRIN) E2805 trial cohort was conducted in order to examine the long-term risk of recurrence in surgically treated renal cell carcinoma (RCC) to ascertain the utility of long-term surveillance. Of the 1,943 individuals involved in the original cohort, 730 acquired recurrence. For individuals at 0, 12, 24, 36, 48, and 60 mo from surgery, the 36-mo cumulative incidences of recurrence were 31%, 26%, 19%, 16%, 19%, and 20%, respectively. At 0 mo from surgery, independent predictors of recurrence were age, pathological T3/4 stage and, N1/2 stage, and Fuhrman grades 3 and 4, nonetheless, this was not observed at 60 mo after surgery. Findings establish that surveillance imaging should be done beyond 5 yr subsequent to surgical resection of intermediate- to high-risk RCC.