Long-term risk of infections after treatment of childhood leukemia: A population-based cohort study using administrative health data
Journal of Clinical Oncology Aug 14, 2019
Pelland-Marcotte MC, Pole JD, Hwee J, et al. - Given that during childhood leukemia treatment, infections are a frequent complication, researchers compared pediatric leukemia survivors after treatment completion vs the general population for the relative rate of infections. For this retrospective, population-based cohort study, they matched 2,204 leukemia survivors from 1992 to 2015 in Ontario, Canada to 11,020 controls. Outcomes suggest that a history of leukemia therapy is significantly associated with an increased risk of infections. Among leukemia survivors, both among the entire cohort and among those without hematopoietic stem-cell transplantation, they noted significantly increased infection-related death. The rate remained elevated more than 5 years from the index date among those whose initial treatment excluded hematopoietic stem-cell transplantation.
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries