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Long-term risk of hospitalization among five-year survivors of childhood leukemia in the Nordic countries

Journal of the National Cancer Institute Feb 15, 2019

Sørensen GV, et al. - Researchers performed this study on five-year survivors of childhood acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML) to comprehensively assess subsequent hospitalization in these subjects. They identified 4,003 five-year survivors in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study. These subjects were diagnosed with childhood leukemia 1970–2008 in Denmark, Sweden, Iceland, and Finland. They followed survivors and 129,828 population comparisons to determine first-time non-psychiatric hospitalizations for 120 disease categories in the hospital registries. They computed standardized hospitalization rate ratios (RRs) and absolute excess risks (AERs) and performed two-sided statistical tests. Findings revealed an increased rate of hospitalization attributed to medical condition among leukemia survivors. In ALL survivors, AML survivors, and in CML survivors, the estimated RR for any hospitalization was 1.95, 3.09, and 4.51, respectively, the RRs remained increased even 20 years from leukemia diagnosis. Corresponding AERs per 1,000 person-years were 28.48, 62.75, and 105.31.
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