Bongiolatti S, et al. - Researchers assessed how overall survival (OS) and disease-free survival (DFS) was influenced by first-time and eventual reiterative surgery in Caucasian patients affected by an invasive adenocarcinoma (ADC) with at least another ground-glass opacity (GGO). They used logistic regression and Kaplan-Meier method to determine the characteristics associated with the evolution of GGOs and OS and DFS, respectively, in 47 patients operated on for lung ADC, identified as main cancer (MC), with at least one synchronous GGO, from January 2003 to March 2017. A surgical reiterative approach was seen to result in good OS and DFS in patients affected by an invasive ADC with at least another GGO nodule. GGO progression requiring treatment was observed in relation to part-solid GGO, but OS remained unaffected by the new onset or evolution of GGOs. The stage of the MC had an impact on DFS.