Kumagai K, et al. - In this retrospective, interventional case series, investigators evaluated the long-term consequences of intravitreal bevacizumab (IVB) or intravitreal tissue plasminogen activator (tPA) or vitrectomy for macular edema correlated with a branch retinal vein occlusion (BRVO). One hundred and sixteen subjects underwent phacovitrectomy with intraocular lens implantation, 41 cases received a single 1.25 mg of IVB injection and followed by pro re nata protocol whereas 71 patients received a single intravitreal tPA. At 1 year following the initial treatment and at the final visit, they noted a significant improvement in the best-corrected visual acuity (BCVA) in all groups. Although, additional surgeries were performed in more than 30% of cases in the IVB and tPA groups.