Svedbom A, Mallbris L, Larsson P, et al. - In this cohort study, researchers described the clinical course of psoriasis and identified possible indicators of long-term outcomes. In total, 721 patients (median [interquartile range] age, 39 [27-55] years; 405 [56%] women) with recent-onset psoriasis (< 12 months duration), 15 years or older were selected using advertising and referrals from a broad range of healthcare settings. Data reported that the cumulative incidence of severe psoriasis at 12 years from enrollment was 21%. According to the findings of this cohort study, combinations of clinical characteristics at onset and activating genes in the IL-23 pathway are significantly related to the clinical course of psoriasis, whereas joint pain and peripheral enthesitis may indicate the likelihood of psoriatic arthritis. Patients who fall under those criteria should be referred to a specialist and monitored more closely. It should be investigated whether early systemic intervention can change the course of the disease.