Rumiz E, et al. - In this study performed on prospectively included 381 consecutive ST-segment elevation myocardial infarction (STEMI) patients who had primary angioplasty and showed multivessel disease (MVD) in the angiogram, researchers evaluated long-term outcomes and predictors of morbi-mortality. A median follow-up of 22 months was carried out among participants [111 (29.1%) were older than 75 (≥75) years and 270 (70.9%) were younger than 75 (<75) years]. The prevalence of MVD in STEMI patients was relevant. A higher incidence of all-cause mortality and major adverse cardiac events (MACE) was seen in patients ≥75 years vs younger patients. In younger patients, incomplete revascularization (IR) was identified as only an independent predictor of MACE. No group showed any association of IR with all-cause mortality risk. The best treatment approach for younguer patients could be a routine complete revascularization (CR) strategy, whereas no clear clinical benefit may be seen in the elderly.