Sheen JJ, et al. - Researchers determined the factors associated with de novo brain cavernoma formations after patients underwent gamma knife radiosurgery (GKRS) were ascertained. In addition, they confirmed if developmental venous anomaly (DVA) presented with a cavernoma and if the cavernoma was included in the GKRS-target location. A retrospective analysis of 80 patients (44 men and 36 women, average age: 39.4 years) with sporadic cavernoma was performed. They located all de novo cavernomas near the brain stem or cerebral peduncle. All of these occurred in the presence of DVAs. They identified the presence of DVA in the radiosurgery-target location as a potentially important factor associated with de novo cavernoma formation.