Nakahama H, et al. - Among 680 consecutive patients (63 ± 11 years old; 66% male) who had intracoronary brachytherapy (ICBT) for coronary in-stent restenosis (ISR), researchers assessed long-term major adverse cardiac events (MACE), such as all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR) at 10-year follow-up. Clinical and angiographic data were analyzed. A high number of smokers 479/680 (70%), hyperlipidemia 638/680 (94%), and multivessel disease 526/680 (77%) were documented as clinical findings of significance. The estimated rate of death, MI, and TVR were 25%, 22.4%, and 48%, respectively, at 10-year follow-up. A consistent rate of death and MI and a decreasing rate of TVR following 5 years was indicated at 10-year follow-up.