Schumacher LED, Sargi ZB, Masforroll M, et al. - This is the first report describing the incidence of long-term opioid use, or risk factors for long-term use, ≥ 1 year after radiotherapy. For persistent opioid use 1-year after curative-intent radiotherapy, records of 276 head/neck cancer patients were retrospectively evaluated. Of note, over the long term, 20 out of 276 patients tended to use opioids. Of note, 7.2% of patients experienced long-term opioid use related to high maximum opioid dosage and early opioid initiation and/or psychotropic/non-opioid analgesics. Clinical conditions are cited as the primary reason for continued use by physicians.