Wu ZY, Kim HJ, Lee JW, et al. - In this retrospective, propensity score–matched case-control study, researchers sought to compare the long-term oncologic outcomes of immediate breast reconstruction (IBR) with nipple-sparing mastectomy (NSM)/skin-sparing mastectomy (SSM) and conventional mastectomy (CM) alone for breast cancer in the setting of neoadjuvant chemotherapy (NACT). This investigation was carried out at Asan Medical Center, Seoul, Korea. In total, 1,266 patients with breast cancer who underwent NACT followed by mastectomy with or without breast reconstruction between January 1, 2010, and November 30, 2016 were involved. In this research, the long-term oncologic outcomes of IBR with NSM/SSM for breast cancer seemed to be similar to those of CM alone after NACT, indicating the feasibility of IBR with NSM/SSM in the NACT setting. Between the two groups, there was no significant difference in 5-year local recurrence–free, disease-free, distant metastasis–free survival rates, and 5-year overall survival rates.