Guttmann A, Blackburn R, Amartey A, et al. - Given a steep rise in the number of women who use opioids in pregnancy, which frequently results in their infants having signs of withdrawal, called neonatal abstinence syndrome (NAS) and recognizing pregnancy as an opportunity to distinguish mothers who may require addiction services and other support to promote their health and that of their families, researchers sought to determine all-cause mortality rate among women whose infants had NAS in the years following birth vs other mothers in both Canada and England. Using linked administrative health data, they developed parallel cohorts of mother–infant dyads in England and Ontario between 2002 and 2012. From England and Ontario, 13,577 and 4,966 mothers of infants with NAS and 4,205,675 and 929,985 control mothers, respectively, comprised study population. The analysis revealed the higher likelihood of mothers with infants with NAS vs mothers of infants without NAS to be living in poverty, having other mental health and addiction problems, and having their infants placed in out-of-home care. Death of 5.1% of English mothers with infants with NAS and 4.6% of Ontarian ones, was reported at 10 years after giving birth, relative to 0.4% of mothers whose infants did not have NAS in both countries. This indicates an 11–12 times greater risk of death linked with prenatal opioid use. Avoidable causes such as intentional and unintentional injuries were evident among the majority of deaths in mothers with infants with NAS. Considering these findings, they recommend clinicians to ensure that mothers of infants with NAS receive accessible services to support their health.