Pasquier E, et al. - A systematic review was undertaken to assess the long-term (≥3-month) impact of Cryptococcal meningitis (CM) (Cryptococcus neoformans and Cryptococcus gattii) on mortality and disability in human immunodeficiency virus (HIV)-infected and non–HIV-infected adults. As per outcomes, CM appeared to have a high long-term impact on survival and disability. One-year mortality ranged from 13% in an Australian non–HIV-infected C. gattii–infected cohort to 78% in a Malawian HIV-infected cohort treated with fluconazole monotherapy. Among survivors, one-year impairment proportions ranged from 19% in an Australian C. gattii cohort to >70% in a Taiwanese non–HIV- and HIV-infected cohorts. Patients’ survival and quality of life could be significantly improved with ongoing early therapeutic interventions, early detection of impairments and access to rehabilitation services.